Endocrine disrupting chemicals during diet-induced weight loss – A post-hoc analysis of the LOWER study

The link between exposure to endocrine disrupting chemicals (EDCs) and the rapid increase in prevalence of obesity has recently been suggested. However, magnitude health impact EDC at-risk populations remain largely unclear. In this study, we investigated effect a dietary intervention driven reduction adipose tissue on urinary mobilization, whether higher leads impaired weight loss obese individuals. post-hoc analysis Lifestyle, OverWeight, Energy Restriction (LOWER) study from Netherlands, 218 subjects were included. Five parabens, three bisphenols thirteen metabolites eight phthalates measured 24-h urine using LC-MS/MS, before after three-months calory-restricted program. Associations adiposity-related traits EDCs tested multivariable linear regression mixed effects models. A multiple testing correction based false discovery rate (FDR) was applied. After 3-month intervention, paraben bisphenol excretions remained similar. Excretions mono-butyl most high-molecular-weight decreased, whereas mono-ethyl phthalate increased (all FDR<0.05). not associated with excretions. Higher baseline post-intervention body-mass index (methyl-, propylparaben), waist circumference (propylparaben, mono-n-butyl phthalate, mono-benzyl phthalate), body fat percentage (mono-ethyl phthalate). parabens index, participants, observed intervention. may lead mobilization successively exposures reduced loss, suggesting obesogenic properties.